Abstract: Base on the Tsai-Wu failure criterion and first order reliability method(FORM),the reliability analysis of a composite material direction pipe is carried out. Secondary development of ABAQUS by using Python language,the finite element program and the reliability analysis method are combined. The reliabilitybased optimization model of a composite material direction pipe is obtained by the combined optimal strategy with multi-island genetic algorithm (MIGA) and sequential quadratic programming (SQP).The results of an example application show that the weight of the composite material direction pipe decreased by 22.5% with the requirement of strength reliability.